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目的 研究胃舒康胶囊对实验性胃粘膜损伤的保护作用并探讨其作用机制。方法 将大鼠随机分为实验组和对照组 ,实验组用不同剂量的胃舒康混悬液 (7 5g/kg、3 75g/kg)每天灌胃 ,1周后用幽门结扎法复制大鼠胃溃疡模型 ,分别于造模后 2h和 18h剖腹取胃 ,测定胃液量、计算溃疡指数 ,观察胃舒康胶囊对实验性胃溃疡的保护作用。结果 胃舒康胶囊能抑制胃液的分泌和显著降低溃疡指数 ,与对照组比较有显著性差异 (P <0 0 5 )。结论 胃舒康胶囊对实验性大鼠胃粘膜损伤具有保护作用
Objective To study the protective effect of Weishukang Capsule on experimental gastric mucosal injury and its mechanism of action. Methods Rats were randomly divided into experimental group and control group. The experimental group was treated with different doses of Weishukang suspension (7 5g/kg, 3 75g/kg) per day. After 1 week, rats were duplicated by pylorus ligation. In the gastric ulcer model, the stomach was taken at 2h and 18h after the modeling, and the amount of gastric juice was measured and the ulcer index was calculated to observe the protective effect of Weishukang Capsule on experimental gastric ulcer. Results Weishukang capsule could inhibit the secretion of gastric juice and significantly reduce the ulcer index, and there was a significant difference compared with the control group (P <0 05). Conclusion Weishukang Capsule has protective effect on gastric mucosal injury in rats