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结直肠癌是常见的消化道恶性肿瘤之一,其浸润转移是患者死亡的主要原因。同源异型框转录因子(CDX2)作为一种新发现的特异性的核转录因子,在正常消化道结肠和小肠上皮的发育中起着关键作用,CDX2基因的表达可显著诱导未分化细胞向肠上皮分化,对肠黏膜的分化与表型的维持、肠上皮细胞的增殖和分化发挥重要作用,对正常和肿瘤型肠上皮均有相对特异性和敏感性[1]。绒毛蛋白
Colorectal cancer is one of the common gastrointestinal malignant tumors. Infiltration and metastasis are the main causes of death. Homeobox transcription factor (CDX2) as a newly discovered specific nuclear transcription factor plays a key role in the development of normal gastrointestinal colon and small intestine epithelium. The expression of CDX2 gene can significantly induce undifferentiated cells to enter the intestine. Epithelial differentiation plays an important role in the differentiation and phenotypic maintenance of intestinal mucosa, the proliferation and differentiation of intestinal epithelial cells, and has relative specificity and sensitivity to normal and tumor type intestinal epithelium [1]. Villin