反义RNA是指能够通过碱基互补与靶RNA(主要是mR NA)特异性结合,抑制靶RNA的功能,从而控制其表达的一类小分子转录物。反义RNA的发现始于原核生物,后来发现真核细胞中也存在天然反义RNA。由于能够选择性地封闭靶基因表达,而且随着近年来反义RNA技术与端粒酶研究的不断深入,构建 Antisense RNA refers to a class of small molecule transcripts capable of controlling the expression of a target RNA by binding to the target RNA (mainly mRNAs) through base complementation and inhibiting the function of the target RNA. The discovery of antisense RNA began in prokaryotes, and later found that natural antisense RNA also exists in eukaryotic cells. Due to the selective closure of target gene expression, and with the recent progress of antisense RNA technology and telomerase research, construction