砷及其氧化物是国内外牙科治疗中用于牙髓失活的主要药物,常用的三氧化二砷与砷(俗称金属砷),它们均以三价砷离子的方式作用,毒性大,使用不当或误服会引起严重组织坏死,甚至中毒致死。 频繁接触和使用此类药物的医务人员对于全面掌握其有关知识,实为重要。为此,笔者就三氧化二砷的理化性质,局部应用的药物作用机理、毒性、用法、用量、不良反应。禁忌症及意外的处置等方面加以概要归纳,提供参考,以求合理应用,减少意外毒性,达到预期的治疗目的。 理化性质:三氧化二砷(亦称无水亚砷酸或亚砷酸酐)为白色质重的粉末或不规则的块状物,并具有同质多晶型(系指药物化学性质相同,物理 Arsenic and its oxides are the main drugs used for dental pulp inactivation in dental treatment at home and abroad. Arsenic trioxide and arsenic (commonly known as metal arsenic) are commonly used as trivalent arsenic ions, which are toxic, improperly used or incorrect Serve can cause serious tissue necrosis, even poisoning to death. It is important for medical personnel who have frequent access to and use of such drugs to have a thorough knowledge of their knowledge. To this end, the author of the physical and chemical properties of arsenic trioxide, topical application of the drug mechanism of action, toxicity, usage, dosage, adverse reactions. Contraindications and accidental disposal of other aspects to be summarized, provide a reference, in order to rational application, reduce accidental toxicity, to achieve the desired therapeutic purpose. Physicochemical properties: Arsenic trioxide (also known as anhydrous arsenic or arsenic anhydride) is a white, heavy powder or irregular lumps, and with polymorphism (means the same chemical properties, physical