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目的 探讨 99m Tc羟基亚甲二磷酸 (MDP) SPECT显像 (MDPSI)、CT、纤支镜 (FB)和肿瘤标志物 (TM)检查诊断肺癌的临床价值。方法 对 6 3例经病理证实的肺肿瘤患者和 10例正常对照进行早期 (5 min) MDPSI,CT、FB和TM检查 ,以病理为标准比较分析诊断效能。结果 肺癌对99m Tc MDP的摄取明显高于良性病灶和正常对照 ,以摄取比值 >1.8为判断标准 ,MDPSI诊断肺癌的灵敏度、特异性和准确率分别为 90 .2 %、90 .9%和 90 .4 % ;CT、FB和 TM分别为 92 .2 %、6 3.6 %和 83.6 %、6 3.9%、10 0 %和 6 9.0 %、6 6 .7%、6 8.2 %和 6 7.1% ;MDPSI和 CT联合诊断肺癌的灵敏度、特异性和准确率分别为 96 .1%、95 .5 %和 95 .9%。结论 MDPSI对肺癌的诊断有较高的临床价值 ,与 CT结合分析可进一步提高肺癌诊断的准确性
Objective To investigate the clinical value of 99m Tc MDP SPECT imaging (MDPSI), CT, fiberoptic bronchoscopy (FB) and tumor marker (TM) in the diagnosis of lung cancer. Methods The early (5 min) MDPSI, CT, FB and TM were performed on 63 pathologically confirmed lung cancer patients and 10 normal controls. The diagnostic efficacy was compared with the pathological criteria. Results The uptake of 99m Tc MDP in lung cancer was significantly higher than that in benign lesions and normal controls. The sensitivity, specificity and accuracy of MDPSI in the diagnosis of lung cancer were 90.2%, 90.9% and 90% respectively .4%; CT, FB and TM were 92.2%, 6 3.6% and 83.6%, 6 3.9%, 10 0% and 6 9.0%, 6.6%, 6 8.2% and 6 7.1%, respectively; The sensitivity, specificity and accuracy of CT and CT in the diagnosis of lung cancer were 96.1%, 95.5% and 95.9% respectively. Conclusion MDPSI has a high clinical value in the diagnosis of lung cancer. Combined with CT, it can further improve the diagnostic accuracy of lung cancer