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目的探讨联合检测IL-6、铁蛋白(SF)和超敏C反应蛋白(hsCRP)在发热患者鉴别诊断中的临床价值。方法将90例发热患者分为细菌感染组(45例)、病毒感染组(15例)和非感染组(30例)。比较三组IL-6、SF和hsCRP的表达差异,并通过ROC曲线分析其对发热患者的诊断价值。结果非感染组IL-6、SF水平高于细菌感染组、病毒感染组(451.80pg/ml vs.81.01pg/ml、11.46pg/ml、986.70ng/ml vs.237.30ng/ml、431.40ng/ml)(P<0.05)。细菌感染组和非感染组hsCRP水平均高于病毒感染组(82.80mg/L和63.90mg/L vs.5.92mg/L)(P<0.05)。不同炎性标志物联合检测较单一指标有更高的诊断价值。结论在发热患者鉴别诊断时,联合检测IL-6、SF和hsCRP可提高诊断灵敏度和特异度。
Objective To investigate the clinical value of combined detection of IL-6, ferritin (SF) and hsCRP in the differential diagnosis of fever patients. Methods 90 cases of fever were divided into bacterial infection group (45 cases), viral infection group (15 cases) and non-infected group (30 cases). The differences of expression of IL-6, SF and hsCRP between the three groups were compared. The diagnostic value of IL-6, SF and hsCRP in patients with fever was analyzed by ROC curve. Results The levels of IL-6 and SF in the non-infected group were higher than those in the bacterial infected group. The virus-infected group (451.80 pg / ml vs 0.81.01 pg / ml, 11.46 pg / ml, 986.70 ng / ml vs.237.30 ng / ml, 431.40 ng / ml) (P <0.05). The hsCRP levels in both bacterial and non-infected groups were significantly higher than those in virus-infected groups (82.80 mg / L and 63.90 mg / L vs. 5.92 mg / L) (P <0.05). The combined detection of different inflammatory markers has a higher diagnostic value than a single indicator. Conclusion In the differential diagnosis of fever patients, combined detection of IL-6, SF and hsCRP can improve the diagnostic sensitivity and specificity.