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为检验清热理气方 (蒲公英 6 0g、黄连 10g、黄芩 10g、枳壳 10g、佛手 12g、炙甘草 6g)对实验性猫胃螺杆菌胃炎的治疗作用。采用复制Balb/c猫胃螺杆菌胃炎模型 ,以清热理气方大、中、小剂量 (分别为 2 6 .6g/kg、 13.3g/kg、 6 .6 5g/kg)给药 ,以三联疗法 (灭滴灵 2 .6mg、四环素 1.3mg、丽珠得乐 1.3mg)为阳性对照组 ,以生理盐水为阴性对照。每组 12只 ,给药 4周 ,末次给药 4周后观察结果。结果 :以猫胃螺杆菌根除为指标 ,清热理气方作用不如三联疗法 ;以重度炎症改善为指标 ,大剂量组优于三联疗法组 ,差别有显著性 (P <0 .0 5)。结论 :清热理气方一方面可以根除猫胃螺杆菌 ,同时对炎症的某些环节可能有比根除猫胃螺杆菌更为重要的作用
To test the therapeutic effects of Qingre Liqi Recipe (dandelion 60g, Coptis chinensis 10g, Radix Astragali 10g, Citrus aurantium 10g, bergamot 12g, Zhigancao 6g) on experimental gastroduodenal gastroenteritis. The Balb/c cat gastroduodenal gastritis model was used to treat large, medium and low doses of Qingre Liqi (26.6g/kg, 13.3g/kg, and 6.65g/kg, respectively). (2.4 mg of metronidazole, 1.3 mg of tetracycline, and 1.3 mg of Livzon Decore) were used as positive control groups and normal saline was used as a negative control. Twelve mice in each group were dosed for 4 weeks and the results were observed after 4 weeks of the last administration. Results: With the eradication of Helicobacter pylori as an indicator, the effect of heat-clearing and qi-elimination was not as good as that of triple therapy, and the improvement of severe inflammation was an indicator. The high-dose group was superior to the triple therapy group, and the difference was significant (P < 0.05). Conclusion: The Qingre Liqi Formula can eradicate S. catotype on the one hand, and at the same time, certain aspects of inflammation may have more important effects than eradication of Helicobacter felis.