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洋地黄应用在医药上已经有近二百年的历史,但对它的使用近来已发生激烈的争论。动物实验证明:不超过治疗剂量2～3倍的洋地黄,可引起致死的心律失常。值得医师们重视的是超剂量洋地黄产生的症状,很象是需要增加剂量的指征。例如心律失常会使医生考虑到给药量不足,但如果再给洋地黄,就会使病人发生更严重的中毒。完全洋地黄化会引起很多副作用。重要的是洋地黄的给药量必需随年龄增大而减少。最常用的制剂地戈辛由肾排泄;而肾的清除功能从30岁起就已经减弱,75～80岁的很多病人不能以55～60岁时的速率来排泄地戈辛。因此其剂量在下列情况时必须减少:老
Digitalis has been used in medicine for almost two hundred years, but its use has been intensely debated recently. Animal experiments show that: no more than 2 to 3 times the therapeutic dose of digitalis, can cause lethal arrhythmia. It is worth the attention of physicians overdose digitalis produced symptoms, much like the need to increase the dose of indications. Arrhythmias, for example, can cause doctors to take into account the lack of medication, but giving digitalis more seriously poisones the patient. Completely yellowing can cause a lot of side effects. It is important that the dose of digitalis must be reduced with increasing age. Goosin, the most commonly used formulation, is excreted by the kidneys; renal clearance has diminished since the age of 30, and many patients between 75 and 80 years of age can not excrete Goosin at 55-60 years of age. Therefore, the dose must be reduced in the following cases: old