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目的:观察定量丝裂霉素应用于小梁切除术中抗增殖的疗效及并发症发生率。方法:慢性闭角型青光眼术48例(66只眼)分两组,用药组小梁切除加丝裂霉素6.6ug应用;对照组单纯小梁切除。比较两组术后滤过泡存在时间及并发症发生率。用UBM检查滤过泡形态及浅前房原因,OCT检查黄斑水肿。结果:用药组33只眼,术后3个月时3只眼滤过泡囊样变。UBM检查1年时31只眼滤过泡形态良好,2只眼包裹瓣下有潜腔。术后Ⅱ°浅前房1只眼。UBM示睫状体浅脱离。对照组术后1年滤过泡粘连8只眼(P=0.039)。2只眼囊变。25只眼滤泡形态良好。术后浅前房Ⅱ°4只眼,UBM示2只眼睫状体脱离。术后1年眼压用药组15.88mmHg±2.64mmHg,对照组15.52mmHg±2.45mmHg。OCT检查无黄斑水肿发生。结论:小梁切除术中小剂量应用丝裂霉素滤过泡形成率高,安全无严重并发症发生。
Objective: To observe the curative effect and complication rate of quantitative mitomycin in trabeculectomy. Methods: 48 cases (66 eyes) with chronic angle-closure glaucoma were divided into two groups. The trabeculectomy group was given trabeculectomy plus 6.6 μg mitomycin C, while the control group was treated by trabeculectomy alone. The duration of postoperative filtering bleb and the incidence of complications were compared between the two groups. UBM check bleb morphology and shallow anterior chamber causes, OCT macular edema. Results: 33 eyes of the medication group, 3 eyes after 3 months of filtration of vesicle-like changes. At 1 year after UBM examination, 31 eyes had good bleb filtering, and 2 eyes had a latent cavity under the flap. Postoperative Ⅱ ° shallow anterior chamber 1 eye. UBM showed shallow ciliary body detachment. One year after operation in the control group, there were 8 eyes with blister adhesion (P = 0.039). 2 eyes cystic change. 25 eyes follicles in good shape. Postoperative shallow anterior chamber Ⅱ ° 4 eyes, UBM showed two eyes ciliary body detachment. One year after operation, intraocular pressure was 15.88mmHg ± 2.64mmHg in control group and 15.52mmHg ± 2.45mmHg in control group. OCT examination no macular edema occurred. CONCLUSION: Mitomycin bleb formation rate is low in trabeculotomy with low dose, safety and no serious complication occurred.