The Darfur issue has been influencing the Sino-U.S. relationship since July 2004. There are at least three reasons to say so. Firstly, China and the U.S. disagree,both on the nature of the issue and on its solution. Secondly,China and the U.S. have conflicting interests, especially their oil interests in Sudan and the African continent.Finally, U.S. domestic political forces have forced the issue onto the agenda of Sino-U.S. relations. Although the issue has become an unharmonious factor in the Sino-U.S.relationship, it has not damaged the bilateral relations too much. Instead, the two countries have been cooperating on the issue.