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目的 大肠癌切除术中相应静脉插管化疗预防肝转移。方法 术中随机进行大肠癌相应部位静脉插管 ,术后立即开始 2 4小时持续静脉点滴 5 Fu 1克 +5 %葡萄糖 10 0 0ml,连用七天 ,化疗后 3～ 5天拔除此管。结果 完成此治疗且观察 3年以上插管组 44例病人及随机对照组的 44例病人 ,近期结果表明 ,插管组与对照组 3年生存率无明显差异 ,分别为 95 .1%( 39/ 41)、93.2 %( 4 1/ 44) ,而无瘤生存率两组有显著差异 ,分别为 85 .4%( 35 / 41)、6 1.4%( 2 7/ 44)。还有待长期随访观察。结论 本项研究是一种不失手术时机、立即对大肠癌术后病人进行预防复发肝转移的积极治疗方法。此方法能广泛应用于大肠癌晚期及未切除的腹腔其它脏器恶性肿瘤的预防及治疗。
Purpose Corresponding intravenous catheter chemotherapy in the prevention of liver metastasis during resection of colorectal cancer. Methods Intraoperative venous catheterization of the corresponding parts of colorectal cancer was performed randomly. Intravenous 5 Fu 1 g + 5% glucose 10 0 0ml was started immediately after the operation for 24 hours. The tube was removed for 7 days and removed 3-5 days after chemotherapy. Results The treatment was completed and 44 patients in the intubation group and the randomized control group of 44 patients over 3 years were observed. The recent results showed that there was no significant difference in the 3-year survival rates between the intubated group and the control group (95.1%, 39 / 41) and 93.2% (41/44), respectively. There was significant difference between the two groups in tumor free survival, which was 85.4% (35/41) and 6.14% (27/44) respectively. Still need long-term follow-up observation. Conclusion This study is a positive treatment for patients with colorectal cancer after operation to prevent recurrence of liver metastases without losing the opportunity of operation. This method can be widely used in the prevention and treatment of advanced and unresectable peritoneal other malignant tumors of colorectal cancer.