论文部分内容阅读
目的 :探讨 IGF- 在肝硬变及肝细胞癌 (HCC)发生发展中的作用及其与不典型增生肝细胞 (L CD)的关系。方法 :运用免疫组织化学 S- P法对 5 7例肝硬变 ,2 9例 HCC癌旁肝组织及 2 1例 HCC进行实验研究。结果 :L CD在肝硬变及癌旁肝组织的发生率分别为 5 6 .1% (32 / 5 7例 )及 6 5 .5 % (19/ 2 9例 )。 IGF- 在 5 7例肝硬变组织、 2 9例癌旁肝组织及 2 1例 HCC中的阳性率分别为 71.9% (41/ 5 7例 ) ,72 .4% (2 1/ 2 9例 )和 47.6 % (10 / 2 1例 ) ,其中伴有 L CD肝组织中 IGF- 阳性率为90 .2 % (46 / 5 1例 ) ,不伴 L CD的肝组织中 IGF- 的阳性率为 45 .7% (16 / 35例 )。结论 :IGF- 的过度表达可能在肝细胞恶性转化早期进程中发挥重要作用 ;L CD可能是肝硬变向 HCC发展过程中的重要中间阶段。
Objective: To investigate the role of IGF-1 in the development of cirrhosis and hepatocellular carcinoma (HCC) and its relationship with atypical hyperplasia hepatocytes (L CD). Methods: Fifty-seven cases of liver cirrhosis, 29 cases of HCC adjacent liver tissues and 21 cases of HCC were studied by immunohistochemical S-P method. Results: The incidence of L CD in liver cirrhosis and adjacent liver tissue were 56.1% (32/57) and 65.5% (19/29) respectively. The positive rates of IGF-1 in 71 cases of cirrhosis, 29 cases of adjacent liver tissues and 21 cases of HCC were 71.9% (41/57), 72.4% (21/29) ) And 47.6% (10/21) respectively. The positive rate of IGF-1 in liver tissues with L-CD liver was 90.2% (46/5) 45.7% (16/35 cases). CONCLUSION: Overexpression of IGF-1 may play an important role in the early stage of malignant transformation of hepatocellular carcinoma. LCD may be an important intermediate stage in the progression of cirrhosis to HCC.