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炔戊菊脂及其二氯衍生物为拟除虫菊酯类杀虫剂,两者化学结构相似。毒性试验两者皆有神经系统症状,如肌颤、抽搐及惊跳反应增强等。炔戊菊脂小鼠吸入4小时LC_(50)>20.00mg/l,经口LD_(50)5280～7940mg/kg,二氯衍生物2小时LC_(50)6.37mg/-l,LD_(50)68.1mg/kg。诱变性检测微核试验两者皆为阴性。Ames 试验炔戊菊脂在高剂量时TA_(100)/-S_g为阳性,而二氯衍生物则为阴性。本文表明炔戊菊脂类的毒性症状、LD_(50)、诱变性皆与化学结构有密切关系,如菊酸中的二甲基被二氯取代后则毒性升高,Ames 试验可能为阴性。
Pyruvate and its derivatives dichloride pyrethroid insecticides, both similar chemical structure. Toxicity tests are both neurological symptoms, such as muscle fibrillation, convulsions and increased reflex reaction. (50)> 20.00mg / l, oral LD505080 ~ 7940mg / kg, dichloro derivative 2 hours LC50507.37mg / l, LD50 ) 68.1 mg / kg. Mutagenicity Test Both micronucleus test were negative. In the Ames test, ethidium was positive for TA_ (100) / - S_g at high doses and negative for dichloro derivatives. This article shows that the toxic symptoms, LD50 (50), mutagenicity of the acetythrins are closely related to the chemical structure. For example, the dimethyl in chrysanthemum is toxic when replaced by dichloroethane, and the Ames test may be negative .