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目的 :观察卵巢癌患者术后化疗辅加冷冻卵巢癌瘤苗激活的肿瘤浸润淋巴细胞 (S- TIL)治疗前后 T淋巴细胞亚群的变化。方法 :将 76例卵巢癌术后行化疗的患者分为 S- TIL 治疗组及对照组。 2组分别于化疗前及治疗后第 7,14,2 1天采外周静脉血检查 T淋巴细胞亚群 ,并进行比较。结果 :治疗组 CD3 +、CD4+、CD8+、CD4+/ CD8+比值在 14d左右即上升 ,与对照组比较有显著性差异 (P <0 .0 5 )。结论 :卵巢癌术后化疗联合应用 S- TIL 治疗可提高机体细胞免疫功能
OBJECTIVE: To observe the changes of T lymphocyte subsets in patients with ovarian cancer before and after chemotherapy combined with frozen-up ovarian cancer vaccine-activated tumor infiltrating lymphocytes (S-TIL). Methods: 76 patients with postoperative ovarian cancer chemotherapy were divided into S-TIL treatment group and control group. The T lymphocyte subsets in peripheral blood were collected and compared before chemotherapy and on the 7th, 14th and 21st days after chemotherapy. Results: The ratio of CD3 +, CD4 +, CD8 + and CD4 + / CD8 + in the treatment group increased on the 14th day, which was significantly different from the control group (P <0.05). Conclusions: Postoperative chemotherapy combined with S-TIL in ovarian cancer can improve cellular immune function