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目的观察不同性激素状态下去势小鼠前列腺组织形态学变化。方法将40只成年balb/c雄性小鼠随机分为正常对照组(N组),去势对照组(C组),去势雄激素组(T组),去势雌激素组(E组)和去势雌雄比例组(R组)。处理4周后,测量血中雌、雄激素含量;观察各组小鼠前列腺指数及前列腺组织学变化;结果和正常组比较,去势后给予不同性激素处理,前列腺指数均有所增加,其中以去势雌雄合剂组最为明显。病理结果显示去势雄激素组前列腺上皮增生明显,间质增生不明显;去势雌激素组前列腺间质肌层增生明显,和正常前列腺比较,上皮成份明显减少;去势雌雄合剂组腺上皮和间质均明显增生,腺体和血管周围可见炎症细胞浸润。结论不同性激素状态下前列腺增生的成份和程度有所不同。其中,雄激素使前列腺上皮增生明显,间质增生不明显;雌激素使前列腺间质肌层增生明显,上皮成份明显减少;雄激素和雌激素共同作用使腺上皮和间质均明显增生,并伴有炎症细胞浸润。
Objective To observe the morphological changes of prostatic tissue in ovariectomized mice under different sex hormones. Methods Forty male Balb / c male mice were randomly divided into normal control group (N group), castration control group (C group), castration androgen group (T group), castrated estrogen group (E group) And castrated male and female ratio group (R group). After 4 weeks of treatment, the levels of estrogen and androgens in the blood were measured. The changes of prostate index and prostatic histology of the mice in each group were observed. Results Compared with the normal group, different sex hormones were administered after ovariectomy, and the prostate index increased Ovariectomy group was the most obvious. The results of pathology showed that prostate epithelial hyperplasia and interstitial hyperplasia were not obvious in castrated androgen group. Prostate interstitial myometrial hyperplasia in castrated estrogen group was significantly decreased compared with that in normal prostate. Epithelium and Interstitial hyperplasia were obvious, inflammatory cells can be seen around the gland and blood vessels infiltration. Conclusions The composition and degree of benign prostatic hyperplasia in different sex hormones are different. Among them, androgen so that prostatic epithelial hyperplasia, interstitial hyperplasia was not obvious; estrogen to prostate interstitial muscle hyperplasia obvious, epithelial components decreased significantly; androgen and estrogen combined to make the glandular epithelium and interstitial were significantly hyperplasia, and With inflammatory cell infiltration.