七十年代头孢菌素的发展,在整个抗生素领域中已占有极其重要的地位,它们的产量逐年增加,新品种不断涌现,较早报道和临床应用的一些头孢菌素见表Ⅰ、Ⅱ(目前有人把它们列为第一代头孢菌素),这些头孢菌素中的任何一个,实际上已具备了各个类型青霉素所表现的抗菌活性,仅有的不足之处是对绿脓杆菌、某些革兰氏阴性杆菌、流感嗜血杆菌和粪链球菌的抗菌作用尚不如羧苄和氨苄青霉素。但近几年来所开发的一些新品种,不仅抗菌作用强,且抗菌谱更广,包括较耐药的吲哚阳性变形杆菌、绿脓杆菌以及偶见致病菌如类杆菌属、沙雷氏菌属等均有较强的抗菌作用,引起了人们极大的注目。有人将这些具有更广谱和超广谱的头孢菌素分别称作为第二代和第三代头孢菌素,它们的差别是:第一代头孢菌素对金黄色葡萄球菌、 Seventies cephalosporin development, in the field of antibiotics has occupied an extremely important position, their production increased year by year, new varieties continue to emerge, some of the earlier reported and clinical application of cephalosporins in Table I, II (currently Some people put them as the first generation cephalosporins), any of these cephalosporins in fact already have the antibacterial activity of various types of penicillin performance, the only downside is the Pseudomonas aeruginosa, some Gram-negative bacilli, Haemophilus influenzae and Streptococcus faecalis antibacterial effect is not as good as carbenicillin and ampicillin. However, some new varieties developed in recent years have not only strong antibacterial activity but also broader antibacterial spectrum, including more resistant strains of indole-positive Proteus, Pseudomonas aeruginosa and occasionally pathogenic bacteria such as Bacteroides, Bacteria, etc. have a strong antibacterial effect, caused a great deal of attention. Some people will have these more broad-spectrum and extended spectrum of cephalosporins were called the second and third generation cephalosporins, respectively, their difference is: first-generation cephalosporins Staphylococcus aureus,