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在清醒自由活动状态的大鼠上，肌醇磷酸酶抑制剂氯化锂、Ｍ受体激动剂氧化震颤素和Ｎ受体激动剂烟碱均可剂量依赖性地降低体温；这三类药物均于腹腔或皮下注射后４０ｍｉｎ发挥效应，９０ｍｉｎ后大鼠体温基本恢复至正常水平；其中氯化锂在５ｄ内反复注射不产生确切的耐受现象。一次性注射氯化锂２ｍｍｏｌ·ｋｇ－１抑制中枢磷酸肌醇降解后，可协同氧化震颤素降低体温的作用，但不影响烟碱降低体温的作用，表明体温调节中枢的Ｍ受体与磷脂酰肌醇代谢之间存在偶联关系，而Ｎ受体与磷脂酰肌醇代谢之间无偶联关系。
In consciously free-moving rats, both the inositol phosphatase inhibitor lithium chloride, the M-receptor agonist oxotremorine and the N-receptor agonist nicotine both lowered the body temperature in a dose-dependent manner; all three drugs 40 minutes after intraperitoneal or subcutaneous injection to exert the effect, 90 minutes after the rat body temperature returned to normal levels; which lithium chloride repeated injection within 5d does not produce the exact tolerance. A single injection of lithium chloride 2mmol · kg-1 inhibition of central phosphoinositide degradation, in combination with oxidative tremor reduces body temperature, but does not affect the role of nicotine to reduce body temperature, indicating that the thermoregulatory center of the M receptor and phosphatidyl There is a coupling relationship between inositol metabolism, and there is no coupling between N receptor and phosphatidylinositol metabolism.