论文部分内容阅读
目的:探讨肾素活性(RA)与血管紧张素Ⅱ(AⅡ)在超排卵治疗中对卵巢过度刺激综合征(OHSS)预测的相关性。方法:用放免法分别测定62例超排卵治疗患者(其中含10例OHSS患者)月经第3天、卵泡成熟日、排卵后7日血清中RA与AⅡ,以20例自然周期患者为对照组。结果:自然周期患者及接受超排卵患者血清中RA与AⅡ在月经第3天无显著性差异(P>0.05),从卵泡成熟日至排卵后7日均呈进行性增高;非OHSS患者肾素活性与血管紧张素Ⅱ值在卵泡成熟日及排卵后7日较自然周期患者增高无显著性差异(P>0.05),但OHSS患者较其余接受超排卵治疗患者明显增高,差异有显著性(P<0.01)。结论:肾素活性与血管紧张素Ⅱ与OHSS的发病密切相关,其增高对OHSS的发病有一定的预测作用。
Objective: To investigate the correlation between renin activity (RA) and angiotensin Ⅱ (AⅡ) in predicting ovarian hyperstimulation syndrome (OHSS) in the treatment of superovulation. Methods: The levels of RA and AⅡ in serum of 62 patients with OHSS (including 10 patients with OHSS) on the 3rd day of menstruation, the mature day of ovarian follicles and the 7th day after ovulation were determined by radioimmunoassay. Twenty patients with natural period were used as the control group. Results: There was no significant difference in serum RA and AⅡ between the patients with natural cycle and the patients receiving superovulation (P> 0.05) on the 3rd day of menstruation, and increased progressively from the mature day to the 7th day after ovulation. The renin There was no significant difference in activity and angiotensin Ⅱ between follicle maturity day and 7th day after ovulation (P> 0.05), but the OHSS patients were significantly higher than the rest patients receiving superovulation (P <0.01). CONCLUSION: Renin activity is closely related to the incidence of angiotensin Ⅱ and OHSS. The increase of renin activity may have a certain effect on the pathogenesis of OHSS.