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本文以化学发光法（ＣＬ）、诱化学发光法（ＩＣＬ）、红细胞变形性（ＥＤ）检测等方法研究了感染伯氏疟原虫（Ｐｌａｓｍｏｄｉｕｍｂｅｒｇｈｅｉ）Ａｎｋａ株的ＢＡＬＢ／ｃ小鼠在注射重组肿瘤坏死因子（ｒＴＮＦ）以后引起脑型疟疾（ＣＭ）时其血浆中活性氧（ＲＯＳ）及相关自由基与ＥＤ及ＥＤ与ＣＭ间的关系。结果发现在ＣＭ出现时动物血浆中ＲＯＳ及相关自由基水平明显增高，ＥＤ明显降低。使用抗氧化剂可以明显改善上述过程而使ＣＭ发生率下降。作者认为，疟原虫感染时ＴＮＦ的过量产生可使宿主吞噬细胞释放大量ＲＯＳ及相关自由基，血浆中这些物质的大量聚集使红细胞变形能力受到破坏，这时红细胞在通过具有极丰富血循环的脑组织时在脑微血管内易于形成广泛性微拴塞，导致ＣＭ形成。
In this study, BALB / c mice infected with Anka strain of Plasmodium berghei (Plasmodiumberghei) were investigated by chemiluminescence (CL), chemiluminescent chemiluminescence (ICL) and erythrocyte deformability (ED) (RTNF) on cerebral malaria (CM) and its relationship with reactive oxygen species (ROS) and related free radicals in ED, ED, ED and CM. The results showed that in the presence of CM, the levels of ROS and related free radicals in animal plasma were significantly increased, while ED was significantly decreased. The use of antioxidants can significantly improve the above process and reduce the incidence of CM. The authors believe that the excessive production of TNF during the infection of Plasmodium can release a large number of ROS and related free radicals in the host phagocytes, and the massive accumulation of these substances in the plasma destroys the deformability of erythrocytes. At this time, the red blood cells pass through brain tissue with extremely rich blood circulation When in the brain micro-easily lead to widespread micro-embolism, leading to CM formation.