目的 :观察高三尖杉酯碱 (HHT)和小剂量阿糖胞苷 (L D- Ara- C)对干扰素 -α(IFN-α)治疗无效的慢性期慢性粒细胞白血病 (CML)的治疗效果。方法 :随机选择 2 5例 IFN- α治疗无效的CML患者经 HHT+L D- Ara- C方案治疗后观察其血液学和细胞遗传学反应。结果 :80 %患者达到血液学缓解 ,32 %患者产生细胞遗传学反应。结论 :HHT+L D- Ara- C方案对于 IFN- α治疗无效的 CML具有较理想的治疗效果 OBJECTIVE: To observe the effects of homoharringtonine (HHT) and low dose of cytarabine (L-Ara-C) on chronic myeloid leukemia (CML) refractory to interferon-α (IFN-α) effect. Methods: Twenty - five CML patients randomly assigned to receive IFN - α therapy were selected for treatment of hematologic and cytogenetic responses after HHT + L D-Ara-C regimen. Results: Hematologic response was achieved in 80% of patients and cytogenetic responses in 32% of patients. Conclusions: The HHT + L D-Ara-C regimen has an ideal therapeutic effect on CML ineffective with IFN-α