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1.资料与方法:口服干扰素组(治疗组)32例,对照组12例,年龄5个月至2岁。两组均静脉或口服补液纠正脱水,治疗组加用干扰素2. 5万 U(用10％萄萄糖溶解至 2～4ml),分 1～2次口服,共服1支。 2.结果:治疗组止泻时间为21.5～68小时,平均28.01±10.04小时;对照组平均止泻时间为95±32.54小时,两组差异非常显著(t=7.0055,P<0.01)。 3.讨论:干扰素的广谱抗病毒作用已被公认,因其耐酸性强,不易被胃酸所破坏,肠道内可保持较高的抗病毒浓度,故口服亦可产生良效。本组口服干扰素无任何不良反应,值得临床推广。
1. Materials and Methods: Oral interferon group (treatment group) 32 cases, control group of 12 cases, aged 5 months to 2 years. Two groups were intravenous or oral rehydration to correct dehydration, the treatment group plus interferon 25000 U (dissolved in 10% glucose to 2 ~ 4ml), 1 or 2 times orally for a total of one. Results: The diarrhea time was 21.5 ~ 68 hours in the treatment group, with an average of 28.01 ± 10.04 hours. The control group had an average of 95 ± 32.54 hours. There was significant difference between the two groups (t = 7.0055, P <0.01). 3. DISCUSSION: The broad-spectrum antiviral effect of interferon has been widely recognized. Because of its strong acid resistance, it is not easily destroyed by gastric acid, and the intestinal tract can maintain a high concentration of antiviral drugs. Therefore, oral administration can also produce good effects. This group of oral interferon without any adverse reactions, it is worth clinical promotion.