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机体存在着两种免疫反应:一种是体液免疫,另一种是细胞免疫。现知细胞免疫反应在抵抗霉菌性、病毒性及细菌性细胞内感染、迟发型变态反应、同种组织器官移植排斥反应、自身免疫反应及肿瘤免疫反应中起着重要的作用。转移因子(Transfer factor,下称TF)是细胞免疫反应中的一种触发剂或增强剂。一、转移因子的发现与进展早在1940年,Landsteine和Chase发现致敏豚鼠的淋巴样细胞能将迟发型变态反应转移给非致敏豚鼠,这是人们首次发现细胞免疫的转移现象。1949年Lawrence成功地将结核菌素(OT)反应阳性的人(供体)的活白细胞,皮下注射于对此反应阴性的人(受体)身上,迅速出现阳性结核菌素皮试反应,说明人的白细胞能转移迟发型变态反应。
There are two types of immune response in the body: one is humoral immunity and the other is cellular immunity. Now known cellular immune response in resistance to fungal, viral and bacterial infections, delayed type of allergic reactions, allograft rejection, autoimmune reactions and tumor immune response plays an important role. Transfer factor (TF) is a trigger or enhancer in cellular immune responses. First, the discovery and progress of the transfer factor As early as 1940, Landsteine and Chase found that sensitized guinea pig lymphoid cells can transfer delayed-type allergic reaction to non-sensitized guinea pigs, which is the first time people found the phenomenon of cellular immunity. In 1949, Lawrence succeeded in rapidly injecting tuberculin (OT) positive human (donor) live leukocytes into the subcutaneous human (recipient) recipient and developing a positive tuberculin skin test, indicating that Human leukocytes can transfer late-type hypersensitivity.