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目的研究瘦素受体基因Gln 223 Arg变异与肥胖合并高血压的关系。方法运用聚合酶链反应-限制性片段长度多态性(PCR-RELP)方法测定无亲缘关系,且有完整临床资料的766例武汉地区汉人的瘦素受体基因Gln 223 Arg变异的基因型(包括252例正常对照者及肥胖合并高血压256例,非肥胖高血压患者136例,单纯肥胖者122例)。结果肥胖合并高血压不同性别,不同瘦素受体基因Gln 223 Arg变异的高血压合并频率比较发现,瘦素受体基因Gln 223Arg变异与男性肥胖合并高血压相关,A等位基因与男性较高的收缩压(P=0.023)及舒张压(P=0.036)及BMI(P=0.031)相关。Logistic回归分析证实,该基因变异是肥胖男性合并高血压的独立风险因子(P=0.036)。携带“A”等位基因的男性肥胖合并高血压发生的比数比(OR)为2.711(95%可信限为1.216、5.129)。结论瘦素受体基因Gln 223 Arg变异与肥胖男性合并高血压相关,收缩压和舒张压及BMI均相关。
Objective To investigate the relationship between the mutation of Gln 223 Arg in obesity and hypertension. Methods The genotypes of Gln 223 Arg mutation in 766 Han Chinese unrelated with complete clinical data were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RELP) Including 252 cases of normal controls and obesity with hypertension in 256 cases, 136 cases of non-obese hypertensive patients, simple obesity in 122 cases). Results Comparisons of the frequency of hypertension with Gln 223 Arg mutations of different leptin receptor genes in obesity with hypertension were found to be associated with the obesity associated with hypertension in men and the high prevalence of allele A in males Systolic blood pressure (P = 0.023) and diastolic blood pressure (P = 0.036) and BMI (P = 0.031). Logistic regression analysis confirmed that the genetic variation was an independent risk factor for obesity in men with hypertension (P = 0.036). The odds ratio (OR) for occurrence of obesity in men with “A” allele was 2.711 (95% confidence interval, 1.216, 5.129). Conclusion Gln 223 Arg mutation of leptin receptor gene is associated with hypertension, systolic and diastolic blood pressure and BMI in obese men.