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糜胰蛋白酶是从猪胰腺中分泌出来的一种天然的肽链内断酶,药理作用与从牛胰中提取的α-糜蛋白酶及胰蛋白酶基本相同,既能像糜蛋白酶那样选择性地水解由芳香族氨基酸(如苯丙氨酸、酪氨酸)所组成的肽键,又能像胰蛋白酶那样选择性地水解由碱性氨基酸(如精氨酸、赖氨酸)所组成的肽键,具有二种酶协同水解蛋白质肽链的作用,更有利于蛋白质的水解。它能促助液化清除血凝块,脓性分泌物和坏死组织等。江苏吴县制药厂在有关单位密切配合下,于1976年首次从我国丰富的猪胰资源中成功地提取了注射用结晶糜胰蛋白酶、外用糜胰蛋白酶之后,又为了使用方便、安全、有效,将结晶糜胰蛋白酶的结晶或重结晶母液及0.65饱和度沉淀部分提取创制成口服糜胰蛋白酶肠溶片,并于1980年7月鉴定通过。
Trypsin is secreted from porcine pancreas as a natural peptide chain-breaking enzyme. Its pharmacological action is basically the same as that of α-chymotrypsin and trypsin extracted from bovine pancreas. It can be selectively hydrolyzed like chymotrypsin Peptide bonds composed of aromatic amino acids such as phenylalanine and tyrosine can selectively hydrolyze peptide bonds consisting of basic amino acids such as arginine and lysine, like trypsin , With two kinds of enzymes synergistic hydrolysis of protein peptide chain role, more conducive to protein hydrolysis. It helps to liquefy blood clots, purulent secretions and necrotic tissue. Jiangsu Wuxian Pharmaceutical Factory in the close cooperation with relevant units, in 1976 for the first time from our rich porcine pancreatic resources successfully extracted the injection of crystallization of trypsin, external use of trypsin, but also for ease of use, safe, effective, will be Crystallization of trypsin crystallization or recrystallization of mother liquor and precipitation of 0.65 saturation precipitation was made into oral trypsin enteric coated tablets, and in July 1980 identified through.