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应用胰岛素、胰高血糖素和生长抑素抗血清，通过免疫组化染色对正常（对照组）和ＳＴＺ诱导的糖尿病大鼠（实验组）胰岛的病理形态进行了观察。结果显示：实验组胰岛Ｂ细胞发生明显变性坏死。对照组与实验组表达胰岛素呈阳性的胰岛分别为９２４％、２３３％，二者之间有显著性差异（Ｐ＜０．００１）。实验组胰岛表达胰高血糖素的Ａ细胞出现明显增生，而Ｄ细胞未见变化。结果提示，ＳＴＺ对胰岛Ｂ细胞具有直接损伤作用；Ａ细胞的增生可能与ＳＴＺ有关，并参与了升高血糖和胰岛素含量降低效应。
Insulin, glucagon and somatostatin antiserum were used to observe the pathological changes of islets in normal (control group) and STZ-induced diabetic rats (experimental group) by immunohistochemistry. The results showed that the experimental group of islet B cells were significantly degeneration and necrosis. The insulin-positive islets in control group and experimental group were 924% and 233% respectively, there was a significant difference between the two groups (P <0.001). The experimental group of pancreatic islet expression of glucagon A cells showed significant proliferation, while no changes in D cells. The results suggest that STZ has a direct damage to islet B cells; A cell proliferation may be related to STZ, and involved in the increase of blood glucose and insulin-lowering effect.