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1例87岁男性患者因肾癌肺转移合并肺部感染入院治疗。入院后患者心电图示房性期前收缩伴偶发室性期前收缩,予以头孢唑肟和左氧氟沙星治疗。住院第5天给予重组人白介素-2 2 100万U+0.9%氯化钠注射液100 ml静脉滴注。次日,患者出现阵发性心房纤颤,2～3次/d,每次持续1～2 min;4 d后心房纤颤频繁发作,发作时间有时10余分钟。给予普罗帕酮100 mg,3次/d口服,效果不佳。考虑可能和重组人白介素-2有关,即刻停药。之后,患者心电图未再出现心房纤颤。
One 87-year-old male patient admitted to hospital for lung cancer with lung metastasis due to renal cell carcinoma. ECG after admission showed atrial premature contractions with occasional ventricular contraction, to be treated with ceftizoxime and levofloxacin. On the 5th day of hospitalization, recombinant human interleukin-21 million U + 0.9% sodium chloride injection 100 ml was given intravenously. The next day, patients with paroxysmal atrial fibrillation, 2 or 3 times / d, each lasting 1 to 2 minutes; 4 days after the frequent episodes of atrial fibrillation, the onset time is sometimes more than 10 minutes. Give propafenone 100 mg, 3 times / d orally, the effect is not good. Consideration may be related to recombinant human interleukin -2, immediate withdrawal. After that, the patient’s ECG did not recur atrial fibrillation.