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目的：观察舒芬太尼对多发伤术后机械通气患者镇痛镇静的效果。方法将30例多发伤术后机械通气患者患者随机分为2组，舒芬太尼组给予负荷剂量0．2μg／kg 后，维持量以每小时0．1μg／kg 持续泵入；芬太尼组给予负荷剂量2μg／kg 后，维持量以每小时1μg／kg 持续泵入。记录两组患者入 ICU 后给药前（T0），给药后1 h（T1），给药后4 h（T2），给药后8 h（T3），给药后24 h （T4）患者生命指征、VAS 评分、Ramsay 评分、机械通气时间与 ICU 住院时间。结果舒芬太尼组在 T2、T3、T4时刻平均血压、心率、呼吸均低于芬太尼组（P ＜0．05），镇痛镇静评分优于芬太尼组（P ＜0．05），机械通气时间与 ICU 住院时间较芬太尼组明显减少（P ＜0．05）。结论舒芬太尼对多发伤术后机械通气患者镇痛镇静有良好的效果。“,”Objective To observe the postoperative analgesic and sedative effects of sufentanil on multi-trauma patients with mechanical ventilation.Method A total of 30 patients were randomly di-vided into 2 groups.Group Sufentanil was given a loading dose of 0.2 μg/kg and a maintaining does of 0.1 μg/(kg·h),and Group Fentanyl was given a loading dose of 2μg/kg and a maintaining does of 1 μg/(kg·h).The vital signs,VAS score,Ramsay score,time of mechanical ventilation,andlength of ICU time were recorded before administration(T0 ),at the time of 1 hour after administration(T1 ),4 hours after ad-ministration (T2 ),8 hours after administration (T3 ),and 24 hours after administration (T4 ).Result Compared with Group Fentanyl,Group Sufentanil had lower mean values of BP,HR,RR,a better analgesic and sedative effects,and shorter time of mechanical ventilation and ICU stay (P <0.05). Conclusion Sufentanil has better postoperative analgesic and sedative effects of on multi-trauma patients with mechani-cal ventilation.