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目的探讨白细胞介素17(IL-17)在宫颈癌患者体内的变化及在宫颈癌诊治的临床意义。方法在2008年1月～2011年12月期间某院共收治宫颈癌患者共73例(宫颈癌组),按照FIGO分期标准其中Ⅰ期24例,Ⅱ期27例,Ⅲ期13例,Ⅳ期9例,按照肿瘤组织学分化程度,其中高分化17例,中分化35例,低分化21例。选取同期因各种原因切除子宫并且病理检查确定宫颈为正常组织的患者40例作为对照人群(宫颈正常组)。进行血清IL-17水平检测。结果 IL-17正常宫颈组(5.58±1.27)pg/ml,宫颈癌组为(57.78±11.36)pg/ml,两组比较差异有统计学意义(t=28.91,P﹤0.05);FIGO分期Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期各期之间比较差异均有统计学意义(P﹤0.05);肿瘤组织学高分化、中分化、低分化患者之间比较差异有统计学意义(P﹤0.05)。结论宫颈癌患者血清IL-17水平较正常人群明显升高,IL-17水平检测有助于对宫颈癌诊断及其治疗,并且对病情发展程度判断亦有一定的临床价值。
Objective To investigate the changes of interleukin 17 (IL-17) in patients with cervical cancer and its clinical significance in diagnosis and treatment of cervical cancer. Methods From January 2008 to December 2011, 73 cases of cervical cancer were treated in a hospital (cervical cancer group). According to FIGO staging criteria, 24 cases were stage Ⅰ, 27 cases were stage Ⅱ, 13 cases were stage Ⅲ, 9 cases, according to the degree of tumor histological differentiation, including 17 cases of well-differentiated, moderately differentiated in 35 cases, poorly differentiated in 21 cases. Select the same period due to various reasons, removal of the uterus and pathological examination to determine the normal tissue of the cervix in 40 patients as a control group (normal cervical group). Serum IL-17 levels were measured. Results There were significant differences between the two groups (t = 28.91, P <0.05). The level of IL-17 in normal cervical group (5.58 ± 1.27 pg / ml, cervical cancer group was 57.78 ± 11.36 pg / There were significant differences between stage, stage Ⅱ, stage Ⅲ and stage Ⅳ (P <0.05). There was significant difference between the patients with well-differentiated, moderately differentiated and poorly differentiated tumors (P < 0.05). Conclusion The serum level of IL-17 in patients with cervical cancer is significantly higher than that in the normal population. The detection of IL-17 is helpful for the diagnosis and treatment of cervical cancer. It also has certain clinical value for judging the extent of disease progression.