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目的观察中、重度子宫内膜异位症病人保守性术后辅助促性腺激素释放激素受体激动药(GnRH-α)、孕三烯酮治疗的临床疗效、安全性及停药后累积复发率、妊娠率及对垂体-卵巢轴内分泌的影响。方法回顾性分析128例中、重度子宫内膜异位症病人,随机分为GnRH-α组、孕三烯酮组和对照组,观察各组的症状缓解率、不良反应、累积复发率和血清性激素水平变化。结果各用药组的症状和体征缓解率均较对照组明显提高(P<0.01);GnRH-α组妊娠率和复发率降低(P<0.05);用药后GnRH-α组血清E2、FSH、LH水平有显著变化(P<0.01),孕三烯酮组LH和E2明显降低(P<0.01)。结论在保守性术后加用抑制卵巢功能药物对提高子宫内膜异位症病人的妊娠率、降低复发率有重要作用。
Objective To observe the clinical efficacy, safety and cumulative recurrence rate of conservative GnRH-α and Gestrinone in patients with moderate and severe endometriosis , Pregnancy rate and its effect on pituitary - ovarian axis endocrine. Methods A retrospective analysis of 128 cases of moderate and severe endometriosis patients were randomly divided into GnRH-α group, gestrinone group and the control group, to observe the symptoms of each group, adverse reactions, the cumulative recurrence rate and serum Sex hormone levels change. Results The symptom and symptom relief rate in each group was significantly higher than that in the control group (P <0.01). The pregnancy rate and recurrence rate were decreased in GnRH-α group (P <0.05) (P <0.01). The LH and E2 of gestrinone decreased significantly (P <0.01). Conclusions It is important to add conservative drugs that inhibit ovarian function to improve the pregnancy rate and reduce the recurrence rate of patients with endometriosis.