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[目的]探讨活血退黄经验方用于婴儿胆汁淤积性肝病的疗效。[方法]2012年11月~2014年4月选取98例诊断为婴儿胆汁淤积性肝病的患儿,随机分成治疗组及对照组各49例,治疗组又按照中医证候分型分为寒湿阻滞证(Ⅰ组)及气滞血瘀证(Ⅱ组)两个亚组。其中对照组采用西医常规治疗,治疗组在对照组的基础上加用桃红四物汤合茵陈蒿汤加减而成的活血利胆经验方,疗程均为4周,于治疗前后观察患儿皮肤巩膜黄染、大小便颜色等临床症状及体征以及血清总胆红素(TBIL)、直接胆红素(DBIL)、谷丙转氨酶(ALT)、总胆汁酸(TBA)、肝脏彩超等实验室指标变化情况,并进行疗效及积分评价。[结果]2组治愈率及总有效率比较,差异有统计学意义(P<0.05);治疗组组间治愈率及总有效率比较,差异无统计学意义(P>0.05);治疗后,治疗组TBIL、DBIL、TBA及肝脏彩超实验室指标均明显下降,差异有统计学意义(P<0.05),而ALT与对照组比较,差异无统计学意义(P>0.05);治疗后,2组中医证候积分比较,差异有统计学意义(P<0.05),治疗组组间中医症候积分差值比较,差异有统计学意义(P<0.05)。[结论]活血退黄经验方对Ⅰ型及Ⅱ型ICH均有显著疗效,对II型ICH中医证候疗效优于Ⅰ型。
[Objective] To investigate the curative effect of activating blood circulation and removing yellow experience on infantile cholestatic liver disease. [Methods] From November 2012 to April 2014, 98 children diagnosed as having cholestatic liver disease were randomly divided into treatment group (49 cases) and control group (49 cases). The treatment group was divided into two groups according to TCM syndrome: Blocking card (Ⅰ group) and qi stagnation syndrome (Ⅱ group) two subgroups. The control group was treated with conventional western medicine. The treatment group was treated with Taohongsiwu Decoction and Yinchenhao Decoction for 4 weeks on the basis of the control group. The changes of sclera The clinical symptoms and signs such as color, stool color, and the changes of laboratory indexes such as serum total bilirubin (TBIL), direct bilirubin (DBIL), alanine aminotransferase (ALT), total bile acid (TBA) , And efficacy and integral evaluation. [Result] The cure rate and total effective rate in the two groups were statistically significant (P <0.05). There was no significant difference in the cure rate and total effective rate between the two groups (P> 0.05) The indexes of TBIL, DBIL, TBA and hepatic color Doppler ultrasound in treatment group were significantly decreased (P <0.05), while there was no significant difference between ALT and control group (P> 0.05) There were significant differences in scores of syndromes of traditional Chinese medicine (P <0.05), differences of TCM syndrome scores between the two groups were statistically significant (P <0.05). [Conclusion] The experiencing prescriptions of activating blood circulation and removing yellow have significant curative effect on both type Ⅰ and type Ⅱ ICH, and the effect of type Ⅱ ICH on TCM syndromes is better than type Ⅰ.