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年长育龄妇女以血FSH上升为其内分泌特点,此时月经周期和排卵功能仍可正常,卵泡期可缩短2～7天,早卵泡期血雌二醇(E_2)及尿E_2代谢产物较育龄期妇女高。有假设该现象是卵巢抑制素(INH)分泌减少,激活素A(activin A,ACT_A)分泌增加所至。为验证此假设,选择5例年长育龄妇女,年龄43～47岁,月经周期规律(≥21天),黄体中期孕酮(P)>6ng/ml,无过度运动或体重过度减轻史,血PRL、TSH正常。另选5例育龄妇女(19～38岁)作正常对照,月经周期25～35天,余条件同年长组。抽取月经周期各天早10点前血,测定E_2、P、FSH、
Women of childbearing age with blood FSH increased to its endocrine characteristics, then the menstrual cycle and ovulation can still be normal, follicular phase can be shortened 2 to 7 days, early follicular phase of blood estradiol (E 2) and urinary E 2 metabolites than child-bearing age High women’s period. It is hypothesized that this is a decrease in the secretion of ovarian inhibin (INH) and an increase in the secretion of activin A (ACT_A). To verify this hypothesis, five older women of childbearing age, aged 43-47 years, menstrual cycle (≥21 days), progesterone (P)> 6ng / ml in mid luteal phase, no history of excessive exercise or overweight, blood PRL , TSH normal. Another 5 cases of women of childbearing age (19 to 38 years old) as a normal control, the menstrual cycle of 25 to 35 days, the remaining conditions the same long group. The menstrual cycle was drawn as early as 10 o’clock before the day of blood, E_2, P, FSH,