目的探讨升压治疗局灶性脑缺血的保护作用及治疗的维持时间。方法40只大鼠随机分为5组:对照组(A组),升压维持时间15min组(B组)、45min组(C组)、90min组(D组)和120min组(E组)。采用大鼠局灶性脑缺血再灌注模型,观察各组脑梗死体积和神经功能缺损评分。结果B、C、D和E组脑梗死灶体积(P<0.01),B、C和D组神经功能缺损评分(P<0.05)均明显低于A组,B组明显低于C、D和E组(P<0.01)。结论缺血3h再灌注时升压维持时间在2h以内对脑损伤有保护作用,升压最佳维持时间是15min。 Objective To investigate the protective effect of boosting therapy on focal cerebral ischemia and the duration of treatment. Methods Forty rats were randomly divided into five groups: control group (group A), maintained at 15 min (group B), 45 min (group C), 90 min (group D) and 120 min (group E). Focal cerebral ischemia-reperfusion model in rats was used to observe the cerebral infarction volume and neurological deficit score. Results The volume of cerebral infarction in groups B, C, D and E was significantly lower than that in group A (P <0.01), and the scores of neurological deficits in groups B, C and D were significantly lower than those in group A Group E (P <0.01). Conclusions The 3 h ischemia reperfusion has a protective effect on the brain injury within 2 hours and the best time to maintain blood pressure is 15 minutes.