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目的检测RegⅣ蛋白在胃癌患者血清中的表达,探讨其作为浸润性胃癌检测标志物的可能性。方法酶联免疫分析法定量检测64例胃癌患者血清中RegⅣ蛋白的表达水平。结果肿瘤浸润至肌层(T_2)和浆膜层(T_3)的胃癌患者血清RegⅣ蛋白水平要显著高于肿瘤局限在黏膜层和黏膜下层(T_1)者(P<0.01);有淋巴结转移者血清RegⅣ蛋白水平要高于无淋巴结转移者(P<0.05);病理Ⅲ期患者血清RegⅣ蛋白水平高于病理Ⅰ期患者(P<0.05)。结论 RegⅣ蛋白可能与胃癌的生长侵袭有关。
Objective To detect the expression of Reg ¢ ñ protein in the serum of gastric cancer patients and explore its potential as a marker of invasive gastric cancer. Methods Enzyme-linked immunoassay was used to detect the expression of Reg Ⅳ protein in serum of 64 patients with gastric cancer. Results The level of serum RegⅣ protein in gastric cancer patients with T 2 and T 3 invasion was significantly higher than that in the tumor with T 1 (P <0.01). The serum levels of RegⅣ protein in patients with lymph node metastasis RegⅣ protein level was higher than those without lymph node metastasis (P <0.05). The level of RegⅣ protein in pathological stage Ⅲ patients was higher than that in stage Ⅰ patients (P <0.05). Conclusions Reg Ⅳ protein may be involved in the growth and invasion of gastric cancer.