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目的 评价不同孕激素治疗有排卵型功能性子宫出血的临床效果。方法 将有黄体功能不全的功能性子宫出血病人 45例随机分为三组 ,均于月经来潮的第 16天开始每日分别服用消各通 0 5mg、 0 2 5mg和安宫黄体酮 8mg,连续 10天 ,观察月经周期、月经量、血红蛋白、伴随症状、子宫内膜病理以及肝肾功能、血糖和血脂的变化。结果 所有病人月经周期转为规律 ,月经量过多者经量减少、贫血纠正 ,与治疗前相比有显著差异 (P<0 0 5 ) ,三组间无明显差异 (P >0 0 5 ) ;血生化指标均在正常范围 ,子宫内膜均转为分泌期 ;少数病人出现体重增加和闭经 ,但与剂量相关 ,多发生于消各通 0 5mg/d组中。 结论 黄体期补充孕激素可改善黄体功能 ,短期使用无明显副作用 ;消各通 0 2 5mg/d和安宫黄体酮 8mg/d为安全有效的治疗剂量。
Objective To evaluate the clinical efficacy of different progestin in treating ovulatory dysfunctional uterine bleeding. Methods Forty-five patients with dysfunctional uterine bleeding were randomly divided into three groups. All patients were treated with 0 5mg, 0 25mg and 8mg progesterone daily, respectively, on the 16th day of menstrual cycle. 10 days, observe the menstrual cycle, menstrual flow, hemoglobin, accompanying symptoms, endometrial pathology and liver and kidney function, blood glucose and blood lipid changes. Results All patients turned into regular menstrual cycles, menstrual flow was reduced, anemia was corrected, there was significant difference compared with before treatment (P <0 05), there was no significant difference between the three groups (P 0 05) ; Blood biochemical indicators are in the normal range, the endometrium were transferred to the secretory phase; a small number of patients with weight gain and amenorrhea, but dose-related, and more occurred in the elimination of all pass 0 5mg / d group. Conclusions Luteal phase of progesterone supplementation can improve the function of corpus luteum, short-term use without obvious side effects; eliminate all pass 025mg / d and progesterone progesterone 8mg / d is a safe and effective therapeutic dose.