耳蜗为重要的听觉感受和传导器官,其损伤后将影响声音信号感受及传导,改变外周听觉传导通路,从而导致听觉中枢产生一系列病理生理改变。本文综述了细胞生长因子、神经营养因子、兴奋性和抑制性氨基酸、原癌基因、抑癌基因等,在耳蜗损伤后,在听觉中枢中表达的变化。但这些因子在 Cochlear is an important auditory sense and conduction organ, its damage will affect the sound signal and conduction, change the peripheral auditory pathway, resulting in a series of pathophysiological changes in the auditory center. This article reviews the changes in the auditory center after cochlear injury, including cell growth factor, neurotrophic factor, excitatory and inhibitory amino acids, proto-oncogene and tumor suppressor gene. But these factors are there