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目的分析分枝杆菌L型(TBL)血流感染和肺癌患者红细胞免疫功能的相关性,为临床治疗提供依据。方法收集2013年1-12月肺结核患者19例、肺癌患者30例及健康体检人员25名为受试者,将其分为肺结核组、肺癌组及健康对照组,采用涂片法和溶血离心培养法检测血液中的分枝杆菌L型,采用常规方法测定血清红细胞和红细胞C3b受体花环率(C3bRR)。结果 3组之间血清红细胞C3b受体花环促进率(RFER)比较差异有统计学意义(P<0.05),抑制率(RFIR)比较差异无统计学意义;TBL阳性组的红细胞沉降率(ESR)升高与TBL阴性组更显著(85.07%与40.35%),差异有统计学意义(P<0.05);TBL阳性组的免疫复合物花环率(ICRR)和C3bRR较TBL阴性组偏低(7.72%与13.62%和16.26%与19.98%),差异有统计学意义(P<0.05);而TBL阳性组与TBL阴性组的RFER有明显降低,88.97%与60.26%,RFIR有一定升高60.07%与59.87%,但两组之间差异均无统计学意义。结论结核分枝杆菌L型血流感染与肺癌患者红细胞免疫功能存在关联。
Objective To analyze the correlation between mycobacterium L - form (TBL) bloodstream infection and erythrocyte immune function in patients with lung cancer and provide basis for clinical treatment. Methods Twenty-nine patients with pulmonary tuberculosis, 30 with lung cancer and 25 healthy people were enrolled in this study from January 2013 to December 2013. The patients were divided into pulmonary tuberculosis group, lung cancer group and healthy control group by smear method and hemolysis Method to detect mycobacterium L type in the blood, and the C3b receptor rosette rate (C3bRR) of serum erythrocyte and erythrocyte was measured by the conventional method. Results There was significant difference in rosette promoting rate (RFER) between the three groups (P <0.05) and RFIR (P> 0.05). The erythrocyte sedimentation rate (ESR) (P <0.05). The ICRR and C3bRR of immunocomplex in TBL-positive group were lower than that in TBL-negative group (7.72%), and the difference was statistically significant And 13.62%, 16.26% and 19.98%, respectively), while the RFER of TBL-positive group and TBL-negative group was significantly lower, 88.97% and 60.26%, RFIR increased by 60.07% and 59.87%, but there was no significant difference between the two groups. Conclusion Mycobacterium tuberculosis L type bloodstream infection is associated with erythrocyte immune function in patients with lung cancer.