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研究了国产ａｚｉｔｈｒｏｍｙｃｉｎ及红霉素等５种大环内酯类抗生素对５２１株临床分离致病菌的体外抗菌作用。结果表明：ａｚｉｔｈｒｏｍｙｃｉｎ对敏感的金葡球菌、肺炎链球菌、化脓性链球菌、淋球菌、嗜血流感杆菌、粪链球菌及脆弱拟杆菌等均具有较好的抗菌作用（ＭＩＣ５０＜０．０１６～０．５ｍｇ／Ｌ）。对敏感的金葡球菌ＭＩＣ５０与ＭＩＣ９０分别为０．０１６与０．０３１ｍｇ／Ｌ，对脆弱拟杆菌ＭＩＣ５０与ＭＩＣ９０分别为０．０１６与０．１２５ｍｇ／Ｌ。ａｚｉｔｈｒｏｍｙｃｉｎ对所测试的多数致病菌的抗菌作用与红霉素相似或稍强，本品与红霉素有交叉耐药性。
In vitro antibacterial activity of 5 macrolide antibiotics, including azithromycin and erythromycin, on 521 clinically isolated pathogens was studied. The results showed that azithromycin has good antibacterial activity against Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Neisseria gonorrhoeae, Haemophilus influenzae, Streptococcus faecalis and Bacteroides fragilis (MIC50 <0.016 ~ 0.5 mg / L). The susceptible Staphylococcus aureus MIC50 and MIC90 were 0.016 and 0.031mg / L, for B. fragilis MIC50 and MIC90 were 0.016 and 0.125mg / L respectively. Azithromycin most of the tested pathogens and erythromycin antibacterial activity similar to or slightly stronger, the goods and erythromycin cross-resistance.