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肠道的屏障功能包括4部分:机械屏障、生物屏障、免疫屏障、化学屏障。正常肠屏障功能的维持依赖于肠黏膜上皮、肠道内正常菌群、肠道内分泌物、蠕动、肠相关免疫细胞等。但肠道是严重烧伤、休克等应激状态下最早易受损的器官,应激状态下肠道屏障功能发生损害能引起一系列病理生理的变化。本文旨在综述应激对肠道屏障功能的影响及其可能的机制,并对目前研究中仍不明确的问题及今后的研究方向进行分析和展望。
Barrier function of the gut includes 4 parts: mechanical barrier, biological barrier, immune barrier, chemical barrier. Normal intestinal barrier function depends on the maintenance of intestinal mucosa epithelial, normal intestinal flora, intestinal secretions, peristalsis, intestinal immune cells and so on. However, the intestine is the earliest organ that is easily damaged under severe burns and shocks. The damage of intestinal barrier function under stress can cause a series of pathophysiological changes. This article aims to summarize the effects of stress on the barrier function of the gut and its possible mechanisms, and to analyze the problems that remain unclear in the present study and the future research directions.