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1例62岁女性2型糖尿病患者因反复出现低血糖入院。血常规检查:嗜酸粒细胞计数和百分比分别为1.72×109/L、25.4%,诊断为嗜酸粒细胞增多症。追问病史,患者因胃窦癌根治术后给予阿地白介素,皮下注射200万U/次,隔日1次,持续4个月余。阿地白介素治疗期间,患者的嗜酸粒细胞计数与百分比逐渐升高如下:第3天,0.02×109/L、2.3%;第11天,0.33×109/L、7.4%;第26天,3.07×109/L、38.7%;第34天,4.21×109/L、47.1%。嗜酸粒细胞升高,考虑与阿地白介素相关。停用阿地白介素,2周后嗜酸粒细胞计数恢复正常。
A 62-year-old woman with type 2 diabetes admitted to hospital for recurrent hypoglycemia. Blood tests: eosinophil count and percentage were 1.72 × 109 / L, 25.4%, diagnosed as eosinophilia. Questioning the medical history, the patient was given ABI after radical surgery of gastric antrum and subcutaneous injection of 2 million U / time, every other day for more than 4 months. The patients’ eosinophil counts and percentages gradually increased during the treatment with aldesleukin as follows: Day 3, 0.02 × 109 / L, 2.3%; Day 11, 0.33 × 109 / L, 7.4%; Day 26, 3.07 × 109 / L, 38.7%; on the 34th day, 4.21 × 109 / L, 47.1%. Eosinophilia is elevated and is thought to be associated with aldesleukin. Aberration of interleukin 2 weeks after eosinophil count returned to normal.