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目的 了解雌三醇栓阴道给药对老年性阴道炎的临床治疗效果。方法 对 135例老年性阴道炎妇女随机分成两组 :90例治疗组每日将含 2mg的雌三醇栓 1枚放入阴道深部 ,1周后每周放入 1枚 ,连用 8周 ;45例对照组用药为含 0 312 5mg倍美力的倍美力软膏 ,用法同治疗组。结果 治疗组和对照组用药后 ,Kupperman评分明显下降 ,阴道健康评分显著升高 ,血清雌二醇 (E2 )水平上升至卵泡早期水平 ,总胆固醇 (TC)下降 ,甘油三酯(TG)及低密度脂蛋白 (LDL)上升 ,但差异无统计学意义 ,治疗组高密度脂蛋白 (HDL)和HDL/LDL显著升高。结论 雌三醇栓能有效缓解围绝经期症候群 ,改善阴道健康状况。
Objective To investigate the clinical effect of vaginal administration of estriol suppository on senile vaginitis. Methods 135 cases of senile vaginitis women were randomly divided into two groups: 90 cases of treatment group will contain 2mg of estriol suppository a day into the deep vagina, 1 week after a week, for 8 weeks; 45 The control group was treated with BeiMei Li Ointment containing 0 312 5mg Betamethan, with the same treatment group. Results After treatment, the Kupperman score was significantly decreased, the vaginal health score was significantly increased, serum estradiol level increased to early follicular level, total cholesterol (TC), triglyceride (TG) and low (LDL) increased, but the difference was not statistically significant. HDL and HDL / LDL were significantly increased in the treatment group. Conclusion Estriol suppository can effectively relieve perimenopausal syndrome and improve vaginal health.