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研究了卟啉类光敏药物主要活性组分：原卟啉（ＰＰ）、血卟啉（ＨＰ）及双卟啉醚、酯混合物（ＤＨＥ）对Ｈｅｌａ细胞（宫颈癌）的光敏杀伤作用特性，首次发现ＰＰ对癌细胞杀伤力最大，是最有效的卟啉组分。进而研究了其作用的分子机制，采用激光喇曼光谱技术，研究了三种组分对溶菌酶空间结构的光敏损伤。结果表明，它们对溶菌酶主链和侧链结构的损伤明显不同：ＰＰ对蛋白质主链结构中的β—折叠，β—回折的光敏损伤明显强于ＨＰ和ＤＨＥ且不随浓度而变．
The phototoxicity of protoporphyrin (PP), hematoporphyrin (HP), bis-porphyrin ether and DHE on Hela cells (cervical cancer) was studied. It is found that PP is the most effective porphyrin component because it has the strongest killing effect on cancer cells. Then the molecular mechanism of its action was studied. Laser Raman spectroscopy was used to study the photosensitizing damage of three components to the spatial structure of lysozyme. The results showed that the lysozyme backbone and side chain structure of the damage was significantly different: PP protein backbone structure of the β-sheet, β-fold back photosensitive damage was significantly stronger than HP and DHE and does not vary with concentration.