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目的观察乙肝病毒标志物阳性肺结核患者抗结核治疗对肝功能损害。方法随机选取同期乙肝病毒标志物阳性肺结核患者和乙肝病毒标志物阴性肺结核患者各50例,分别设定为观察组与对照组,均采用相同的抗结核药物治疗。比较分析2组患者肝功能损害情况、损害时间、恢复时间及治疗前后肝功能变化。结果观察组肝功能损害发生率为66.00%,高于对照组的22.00%(P<0.01);抗结核治疗后ALT、AST及TBIL肝功能指标比较,观察组均高于对照组(P<0.01);观察组肝功能损害发生时间为(34.1±7.3)d,早于对照组的(48.2±10.2)d(P<0.01);肝功能恢复时间为(24.5±5.5)d,晚于对照组的(13.4±3.0)d(P<0.01)。结论抗结核药物对乙肝病毒标志物阳性肺结核患者的肝功能影响较严重,须密切观察并监测患者的乙肝病毒标志物以及肝功能指标的变化情况。
Objective To observe the anti-TB treatment of patients with hepatitis B virus positive pulmonary tuberculosis on liver dysfunction. Methods Randomly selected 50 cases of hepatitis B virus positive pulmonary tuberculosis patients and hepatitis B virus negative pulmonary tuberculosis patients in the same period, which were set as the observation group and the control group, all treated with the same anti-TB drugs. Comparative analysis of two groups of patients with liver damage, damage time, recovery time and changes in liver function before and after treatment. Results The incidence of hepatic dysfunction in the observation group was 66.00%, which was higher than that in the control group (22.00%, P <0.01). The indexes of ALT, AST and TBIL in the observation group were higher than those in the control group (P <0.01) ). The onset time of liver dysfunction in the observation group was (34.1 ± 7.3) days, which was earlier than that in the control group (48.2 ± 10.2 days) (P <0.01), and the recovery time of liver function was (24.5 ± 5.5) (13.4 ± 3.0) d (P <0.01). Conclusion Anti-TB drugs have a more serious effect on the liver function of hepatitis B virus positive pulmonary tuberculosis patients. Hepatitis B virus markers and changes of liver function indexes should be closely observed and monitored.