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目的了解新生HBV感染状况,以加强对HBV的预防和控制,为今后的防治工作提供科学依据。方法对2008年入学的6 322名新生用酶联免疫法(EL ISA)检测病毒性乙型肝炎五项血清学标志及测定ALT(丙氨酸氨基转移酶)。结果HBsAg阳性率为6.52%,性别间差异有显著性(P<0.01),其血清学标志物阳性模式(单纯HBsAb阳性除外)有12种,以HBsAg+HBeAg+抗-HBc阳性;HBs Ag+抗-HBe+抗-HBc阳性;HBs Ag+抗-HBc三种模式多见,其构成比分别为26.82%,28.89%,13.67%。HBs Ag阳性者与阴性者ALT异常率分别为1.46%及0.36%,两者之间差异有显著性(P<0.01)。结论为预防和控制乙肝在高校的传染,在新生中应加强乙型肝炎感染的控制和预防工作。
Objective To understand the status of newborn HBV infection in order to strengthen the prevention and control of HBV and provide a scientific basis for prevention and treatment in the future. Methods Five serological markers of viral hepatitis B were detected by enzyme-linked immunosorbent assay (ELISA) in 6 322 freshmen admitted in 2008 and ALT (alanine aminotransferase) was determined. Results The positive rate of HBsAg was 6.52%, there was significant difference between the sexes (P <0.01). There were 12 positive serological markers except HBsAb except HBsAg + HBeAg + HBe + anti-HBc positive; HBs Ag + anti-HBc more common three patterns, the constituent ratio was 26.82%, 28.89%, 13.67%. The abnormal rates of ALT in HBsAg-positive and -negative patients were 1.46% and 0.36%, respectively, with significant difference (P <0.01). Conclusion In order to prevent and control hepatitis B infection in higher education, the control and prevention of hepatitis B infection should be strengthened in freshmen.