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目的探讨硫氧还蛋白还原酶(TrxR)在肺癌治疗中的表达及诊断价值。方法选取2013年1月至2015年12月青岛市胶州中心医院放疗科收治的80例肺癌患者为观察组,另选取医院同期健康查体者80名为对照组。检测比较两组空腹血清TrxR活性表达水平,分析TrxR在肺癌中的表达。结果肺癌患者血清中TrxR活性表达水平明显高于对照组,差异有统计学意义(P<0.05)。肺癌3种不同组织类型中,而鳞癌及腺癌者之间相比,差异无统计学意义(P>0.05),而小细胞肺癌与鳞癌、腺癌血清中TrxR活性表达水平比较,差异有统计学意义(P<0.05)。Ⅲ~Ⅳ期肺癌血清TrxR活性表达水平显著高于Ⅰ~Ⅱ期肺癌,肺癌伴有淋巴结及远处转移者TrxR活性表达水平明显高于无淋巴结及远处转移者。结论 TrxR活性水平与肺癌的发生、临床分期、转移等密切相关,充分地监测肺癌患者不同时期的血浆TrxR值,对临床诊疗有指导意义。
Objective To investigate the expression and diagnostic value of thioredoxin reductase (TrxR) in the treatment of lung cancer. Methods Eighty lung cancer patients admitted to the Department of Radiation Oncology, Jiaozhou Central Hospital of Qingdao City from January 2013 to December 2015 were selected as the observation group, and 80 healthy controls were selected as the control group. The levels of TrxR activity in fasting serum of two groups were detected and compared, and the expression of TrxR in lung cancer was analyzed. Results The serum level of TrxR in lung cancer patients was significantly higher than that in the control group (P <0.05). There was no significant difference between squamous cell carcinoma and adenocarcinoma (P> 0.05), while the expression of TrxR in small cell lung cancer, squamous cell carcinoma and adenocarcinoma serum were different There was statistical significance (P <0.05). The expression of TrxR in stage Ⅲ-Ⅳ lung cancer serum was significantly higher than that in stage Ⅰ-Ⅱ lung cancer. The expression of TrxR in lung cancer with lymph node and distant metastasis was significantly higher than those without lymph node and distant metastasis. Conclusion The level of TrxR activity is closely related to the occurrence, clinical stage and metastasis of lung cancer. It is instructive to monitor the plasma TrxR in different stages of patients with lung cancer.