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蛋白酪氨酸磷酸酶家族由130多种蛋白酪氨酸磷酸酶组成,它们和蛋白质酪氨酸激酶家族一起调控蛋白质中酪氨酸残基的磷酸化以及去磷酸化的动态平衡,它们的活性直接决定细胞内蛋白质的磷酸化水平的高低。SHP-2是蛋白酪氨酸磷酸酶家族的一员,在各种细胞和组织中均有广泛的表达,参与多个信号传导通路,介导细胞的生长、分化、迁移、粘附及凋亡等。SHP-2的表达异常会导致多种疾病的产生,但是相关综述较少,同时未见文献报道其在胶质瘤中的作用,因此本文简要介绍SHP-2的结构、功能、信号传导,并阐述了SHP-2与常见疾病的关系。
The protein tyrosine phosphatase family consists of more than 130 protein tyrosine phosphatases that, along with the protein tyrosine kinase family, regulate the phosphorylation and dephosphorylation of tyrosine residues in proteins, their activity Directly determine the level of intracellular protein phosphorylation level. SHP-2, a member of the protein tyrosine phosphatase family, is widely expressed in various cells and tissues and participates in multiple signaling pathways and mediates cell growth, differentiation, migration, adhesion and apoptosis Wait. The abnormal expression of SHP-2 leads to many diseases, but there are few related reviews and no reports about the role of SHP-2 in gliomas. Therefore, we briefly introduced the structure, function and signal transduction of SHP-2 Describes the relationship between SHP-2 and common diseases.