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目的观察婴幼儿持续性腹泻(Persistent diarrhea,PD)发锌及血锌水平变化;探讨甘草锌佐治婴幼儿PD的有效性。方法测定87例PD婴幼儿和100例健康婴幼儿的发锌、血锌水平,比较其差异及相关性;将87例PD婴幼儿随机分为两组,对照组常规治疗,补锌组在常规治疗基础上加用甘草锌治疗,并观察疗效。结果 PD婴幼儿的发锌、血锌水平低于正常婴幼儿(P<0.01),发锌与血锌高度相关(r=0.824,P<0.001);补锌组治疗2周后发锌、血锌值含量较治疗前增加(P<0.05)。补锌组患儿治疗总有效率(86.3%)明显高于对照组(76.2%),差别有统计学意义(P<0.05)。止泻时间补锌组(4.8±2.1)d,短于对照组(6.4±2.9)d,差别有统计学意义(P<0.05)。结论持续性腹泻婴幼儿发锌、血锌水平均低于健康儿;发锌检测可以较准确反映出锌营养水平;在常规治疗的基础上辅以甘草锌治疗PD可以缩短腹泻时间,提高临床治愈率,有明显的疗效。
Objective To observe the changes of zinc and zinc levels in infants with persistent diarrhea (PD) and to explore the efficacy of zinc glycyrrhizinate in infants with PD. Methods 87 cases of PD infants and 100 healthy infants were assayed for zinc and zinc levels, and their differences and correlations were compared. 87 cases of infants and young children were randomly divided into two groups. The control group received routine treatment, On the basis of treatment plus licorice zinc treatment, and observe the effect. Results The levels of zinc and blood zinc in PD infants and young children were lower than those in normal infants (P <0.01). Hair zinc was highly correlated with blood zinc (r = 0.824, P <0.001) Content increased than before treatment (P <0.05). The total effective rate (86.3%) in zinc supplementation group was significantly higher than that in control group (76.2%), the difference was statistically significant (P <0.05). The duration of antidiarrheal was (4.8 ± 2.1) d in the zinc-supplement group, which was shorter than that in the control group (6.4 ± 2.9) d, with a significant difference (P <0.05). Conclusions Infants with persistent diarrhea have lower levels of zinc and blood zinc than healthy children. Hair zinc test can accurately reflect the level of zinc nutrition. On the basis of conventional treatment, supplementation of zinc and licorice zinc can shorten diarrhea and improve clinical cure Rate, there is a significant effect.