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用放射免疫测定法测定了４６例正常人和９０例不同牙周袋深度牙周炎患者龈沟液中前列腺素Ｅ_２的水平结果表明，所有各类不同深度的牙周炎患者龈沟液中前列腺素Ｅ_２值均比正常人高，且具有统计学意义；前列腺素Ｅ_２值随牙周袋深度加深而升高，尤其袋深超过６ｍｍ以上者前列腺素Ｅ_２水平升高更为明显，且有统计学意义。本试验证实龈沟液中前列腺素Ｅ_２水平与牙周炎骨破坏的严重程度相关。
The levels of prostaglandin E2 in gingival crevicular fluid of 46 normal subjects and 90 patients with different periodontal pocket depth periodontitis were measured by radioimmunoassay. The results showed that in all kinds of periodontitis patients with different depths, The values of E_2 were higher than those in normal controls, and the values of prostaglandin E_2 increased with the depth of periodontal pocket. Especially when the pocket depth was more than 6mm, the level of prostaglandin E_2 increased more obviously significance. This experiment confirmed that the level of prostaglandin E_2 in gingival crevicular fluid was related to the severity of bone destruction in periodontitis.