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三、临床对新药的估价 (一)临床实验的目的及步骤通过上述一系列的动物实验,使我们对新药的作用有了一个概括的认识。只有少数具有选择性药理作用,或对动物的某种病理状况有良好影响,并且毒性较低者,始有希望成为在临床上有实际应用价值的药物。但是,动物实验结果和临床实践间还有一段很长的距离。只有通过临床试用,才能缩短此距离,为新药的应用作出正确的估价。临床试用之所以必要,可举几个实例来说明:(1)许多能升高动物血压的药物,不能升
Third, the clinical evaluation of new drugs (a) the purpose and steps of clinical trials Through the series of animal experiments, so that we have a general understanding of the role of new drugs. Only a small number of selective pharmacological effects, or a certain pathological condition in animals have a good impact, and less toxic, there is hope to become clinically practical value of the drug. However, there is still a long way to go between experimental animal experiments and clinical practice. Only through clinical trials can we shorten this distance and make the correct appraisal for the new drug application. The reason why clinical trials are necessary, can give a few examples to illustrate: (1) many drugs that can raise blood pressure in animals, can not rise