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目的探讨氯吡格雷对急性脑梗死患者P-选择素(Ps)的影响和意义。方法 56例急性脑梗死患者作为观察组,并选取同期健康体检者52例作为对照组,采用酶联免疫吸附实验(ELISA)法检测两组血浆Ps水平,观察并比较观察组治疗前后和对照组Ps水平。结果观察组患者治疗前Ps(18.32±2.91)ng/L水平明显高于对照组(5.36±1.01)ng/L(P<0.05),观察组治疗后Ps水平(5.62±1.21)ng/L显著低于治疗前水平(P<0.05),但与对照组比较差异无统计学意义(P>0.05)。结论急性脑梗死患者在急性期血小板功能处于活跃状态,可能与Ps的升高有关,在脑梗死急性期的治疗中同时使用抗血小板药物对于患者的预后具有重要意义。
Objective To investigate the effect of clopidogrel on P-selectin (Ps) in patients with acute cerebral infarction and its significance. Methods Fifty-six patients with acute cerebral infarction were selected as observation group and 52 healthy subjects were selected as control group. Plasma Ps levels were measured by enzyme-linked immunosorbent assay (ELISA) in both groups before and after treatment Ps level. Results The level of Ps in the observation group before treatment was obviously higher than that in the control group (5.36 ± 1.01) ng / L (P <0.05). The Ps level in the observation group was significantly higher than that in the control group (5.62 ± 1.21) ng / L Lower than that before treatment (P <0.05), but no significant difference compared with the control group (P> 0.05). Conclusions Patients with acute cerebral infarction are active in acute phase of platelet function, which may be related to the increase of Ps. The simultaneous use of antiplatelet drugs in the treatment of acute cerebral infarction is of great significance for the prognosis of patients.