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本文观察了22例放置孕酮宫内节育器和19例放置不含孕酮的宫内节育器妇女上环前及上环后月经第一天之月经血及周围静脉血中纤溶活性、抗凝血酶Ⅲ(AT-Ⅲ)和因子Ⅷ相关抗原(ⅧR:Ag)的变化。以探讨放置孕酮宫内节育器后经血量减少的机制。结果表明:放置孕酮IUD妇女经血量减少的机制既不是AT-Ⅲ活力的变化,亦不是通过合成、释放ⅧR∶Ag的增加从而加强血小板的粘附作用。而经血中纤溶活性的降低则可能是置孕酮IUD者经血量减少的重要机制之一。
In this paper, 22 cases of progesterone IUD and 19 cases of women without progesterone IUD were observed in the menstrual blood on the first day after menstruation and the peripheral fibrinolytic activity in the peripheral blood Thrombin Ⅲ (AT-Ⅲ) and factor Ⅷ related antigen (Ⅷ R: Ag) changes. To investigate the placement of progesterone IUD after menstrual flow mechanism. The results showed that the mechanism of menstrual blood volume reduction in women with progesterone IUD was neither the change of AT-Ⅲ activity nor the increase of platelet adhesion through the synthesis and release of ⅧR: Ag. The decline in menstrual fibrinolytic activity may be set progesterone IUD one of the important mechanisms of blood loss.